With the advent of combined antiretroviral therapy (cART), people with HIV are living much longer and infection can be treated as a chronic disease. We demonstrated that 213Bi-2556 mAb crossed an in-vitro human blood brain barrier and specifically killed transmigrated HIV-infected PBMCs and monocytes without overt damage to the barrier. No overt damage to barriers was observed. 213Bi-2556 killed significantly more transmigrated HIV-infected cells in comparison to 213Bi-1418 and uninfected cells. The isoelectric point of 213Bi-2556 was 9.6 enabling its penetration through the barrier by transcytosis. The barriers were examined by confocal microscopy for overt damage. Killing of cells was measured by TUNEL and Trypan blue assays. To assess the ability of 213Bi-2556 to kill the HIV-infected cells on the CNS side of barrier, the HIV-infected and uninfected PBMCs and monocytes were allowed to transmigrate across the barriers overnight followed by application of 213Bi-2556 or control mAb 213Bi-1418 to the top of the barrier. The ability of radiolabeled 2556 to penetrate through the barrier was studied by adding it to the upper chamber of the barriers and its penetration into the CNS side was followed for 5 h. Methods:Ģ556 mAb isoelectric point was determined with isoelectric focusing. Here we tested the ability of 213Bi-2556 to cross a tissue culture model of the human blood brain barrier and kill HIV-infected peripheral blood mononuclear cells (PBMCs) and monocytes on the CNS side of the barrier. Radiolabeled human mAb 2556 to HIV gp41 selectively kills HIV-infected cells in vivo and in vitro. There is a need for therapeutics that can enter the central nervous system (CNS) and eradicate the virus. Many HIV patients on combined antiretroviral therapy exhibit HIV-associated neurocognitive disorders because the brain becomes a viral reservoir.
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Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website ( ). Supplemental digital content is available for this article. *Currently at Children's Hospital Los Angeles, Los Angeles, California, USA.Ĭorrespondence to Ekaterina Dadachova, PhD, Albert Einstein College of Medicine of Yeshiva University, 1695A Eastchester Rd, Bronx, NY 10461, USA.
I'm sure there are more elegant ways of solving this problems, but hey, at least it works.AAlbert Einstein College of Medicine, Bronx, New York, USAīEuropean Commission, Joint Resaerch Centre, Institute for Transuranium Elements, Karlsruhe, GermanyĭNew York Veterans Affairs Harbor Healthcare System, New YorkĮPublic Health Research Institute, NewarkįDepartment of Microbiology and Molecular Genetics, Rutgers New Jersey Medical School, Rutgers The State University of New Jersey, Newark, New Jersey, USA.
11, 12 13" I included an If selection to add a 0 before the total page count if said number is lower than 10. Since the automatic page numbering format used in the document is " 01, 02, 03. The macro runs in background without the need of active input and refreshes the content of the target text box on every page change. Y in Shapes(Y) identifies the target text box. X In mp.Item(X) identifies your master page (in case you have more than one). Here's a working macro for anyone with the same problems Private WithEvents PubApp As Publisher.Application So, I accomplished the first half of my goal, but I need some help with the rest. The macro automatically starts when the document is opened and creates a popup with the total page number every time the user changes page. Private Sub PubApp_WindowPageChange(ByVal Vw As View) What I have right now: Private WithEvents PubApp As Publisher.Application The textbox should show "page X of Y", but due to publisher limitations only the "X" is automatically updated without using a macro. I want to create a macro that automatically starts when the document is opened and as frequently as possible updates a textbox in the master page.
I decided to look into macros for a solution, but with my limited knowledge of VBA I only managed to get so fat before hitting a roadblock.
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Recently I have been struggling with publisher at work, and the most recent source of concern is the software inability to give something a simple as an auto-updating "total pages" count.
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