Platelet levels cycle between low 500s and mid 700s typically. When my platelet levels get up towards 800K my von Willebrand Factors tend to drop below norm, but I do not have Acquired von Willebrand Disease. When on aspirin, I have tended to bleed too much and bruise far too easily. Despite 30+ years of a MPN - I have never had a single incident of thrombosis. My mutant allele burden is only 25% - it has not been retested. I am following a phlebotomy-only protocol. Fortunately, I do not need cytoreduction per the MPN-expert doc I consulted. This last time (last year) I had toxic effects even a very low dose, so it appears that I am now hydroxyurea-intolerant. I have been on hydroxyurea for three 1 -year periods of time over the course of 30 years when my platelet levels spiked. I have never taken interferon or ruxolitinib. I actually have more trouble with the inflammation related issues that accompany the JAK2 mutation than the blood cell numbers per se. Still alive and kicking! Have had and continue to have a good life despite the MPN. It progressed to Polycythemia Vera (PV) about 7 years ago. įYI - I was diagnosed with Essential Thrombocytosis (ET) over 30 years ago.
Here is a link to patient recommended MPN-expert docs. If you have not already seen a MPN specialist (not all hematologists have this expertise), then it is worth finding one to consult. Inflammation, bleeding, tissue damage - all con trigger platelet production. Inflammation is a trigger for platelet production. triple negative ET), it could also be some form of a reactive thrombocytosis going on. While it could be one of the more atypical Myeloproliferative Neoplasms (MPN) (e.g. It certainly seems like something is going on. Do please keep up the investigating until you get it figured out. Epub 2015 Oct 30.Well this sounds like a real mystery and not the kind we enjoy reading. Sex-specific differences in genetic and nongenetic determinants of mean platelet volume: results from the Gutenberg Health Study. Panova-Noeva M, Schulz A, Hermanns MI, et al. Standardization and reference intervals of platelet volume indices: Insight from the Brazilian longitudinal study of adult health (ELSA-BRASIL). Reference intervals for mean platelet volume and immature platelet fraction determined on a sysmex XE5000 hematology analyzer. Scand J Clin Lab Invest. 2016 76(2):172-6.
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Mean platelet volume is increased in infective endocarditis and decreases after treatment. Panova-noeva M, Schulz A, Hermanns MI, et al. Coronary artery bypass grafting in idiopathic thrombocytopenia: use of thromboelastometry without platelet transfusion. Mean Platelet Volume (MPV) as an indicator of disease activity and severity in lupus.
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